Annotation Detail
Information
- Associated Genes
- ACE
- Associated Variants
-
GRK4 p.Val486Ala (p.V486A)
(
ENST00000345167.10,
ENST00000398051.8,
ENST00000398052.9,
ENST00000504933.1 )
GRK4 p.Ala533Val (p.A533V) ( ENST00000345167.10, ENST00000398051.8, ENST00000398052.9, ENST00000504933.1 )
GRK4 p.Val486Ala (p.V486A) ( ENST00000345167.10, ENST00000398051.8, ENST00000398052.9, ENST00000504933.1 )
GRK4 p.Ala533Val (p.A533V) ( ENST00000345167.10, ENST00000398051.8, ENST00000398052.9, ENST00000504933.1 ) - Associated Disease
- obesity
- Source Database
- DisGeNET
- Description
- Among girls, the obesity risk increased in GRK4 A486V heterozygote and CYP11β-2 mutant homozygote although sodium intake was relatively lower, implying that ACE, SLC12A, CYP11β-2, and GRK4 A486V polymorphisms showed gender-based differences with regard to interaction between sodium intake and obesity.
- Pubmed
- 25768006
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.139208137073453
- Year of publication
- 2015
Drugs