Annotation Detail

Information
Associated Genes
SCN5A
Associated Variants
SCN5A p.Asp1275Tyr (p.D1275Y) ( ENST00000333535.9, ENST00000413689.6, ENST00000414099.6, ENST00000423572.7, ENST00000449557.6, ENST00000450102.6, ENST00000455624.6 )
SCN5A p.Asp1275Asn (p.D1275N) ( ENST00000414099.6, ENST00000423572.7, ENST00000333535.9, ENST00000450102.6, ENST00000455624.6, ENST00000449557.6, ENST00000413689.6 )
SCN5A p.Asp1275Tyr (p.D1275Y) ( ENST00000333535.9, ENST00000413689.6, ENST00000414099.6, ENST00000423572.7, ENST00000449557.6, ENST00000450102.6, ENST00000455624.6 )
SCN5A p.Asp1275Asn (p.D1275N) ( ENST00000333535.9, ENST00000413689.6, ENST00000414099.6, ENST00000423572.7, ENST00000449557.6, ENST00000450102.6, ENST00000455624.6 )
Associated Disease
Cardiomyopathy, Dilated
Source Database
DisGeNET
Description
The D1275N SCN5A mutation has been associated with a range of unusual phenotypes, including conduction disease and dilated cardiomyopathy, as well as atrial and ventricular tachyarrhythmias.
Pubmed
21824921
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.133430135385438
Year of publication
2011
Drugs