Annotation Detail

Information
Associated Genes
NF1
Associated Variants
NF1 p.Cys93Tyr (p.C93Y) ( ENST00000696138.1, ENST00000358273.9, ENST00000691014.1, ENST00000356175.7, ENST00000431387.8, ENST00000487476.5, ENST00000490416.2 )
NF1 p.Leu604= (p.L604=) ( ENST00000691014.1, ENST00000356175.7, ENST00000696138.1, ENST00000358273.9 )
NF1 p.Leu604Val (p.L604V) ( ENST00000358273.9, ENST00000696138.1, ENST00000356175.7, ENST00000691014.1 )
NF1 p.Leu844Pro (p.L844P) ( ENST00000358273.9, ENST00000696138.1, ENST00000691014.1, ENST00000356175.7 )
NF1 p.Leu844Arg (p.L844R) ( ENST00000358273.9, ENST00000696138.1, ENST00000356175.7, ENST00000691014.1 )
NF1 p.Leu898Pro (p.L898P) ( ENST00000696138.1, ENST00000358273.9, ENST00000356175.7, ENST00000691014.1 )
NF1 p.Cys93Tyr (p.C93Y) ( ENST00000356175.7, ENST00000358273.9, ENST00000431387.8, ENST00000487476.5, ENST00000490416.2, ENST00000691014.1, ENST00000696138.1 )
NF1 p.Leu604= (p.L604=) ( ENST00000356175.7, ENST00000358273.9, ENST00000691014.1, ENST00000696138.1 )
NF1 p.Leu604Val (p.L604V) ( ENST00000356175.7, ENST00000358273.9, ENST00000691014.1, ENST00000696138.1 )
NF1 p.Leu844Pro (p.L844P) ( ENST00000356175.7, ENST00000358273.9, ENST00000691014.1, ENST00000696138.1 )
NF1 p.Leu844Arg (p.L844R) ( ENST00000356175.7, ENST00000358273.9, ENST00000691014.1, ENST00000696138.1 )
NF1 p.Leu898Pro (p.L898P) ( ENST00000356175.7, ENST00000358273.9, ENST00000691014.1, ENST00000696138.1 )
Associated Disease
neurofibromatosis 1
Source Database
DisGeNET
Description
These children exhibited a constitutional genetic instability associated with clinical features of de novo neurofibromatosis type 1 (NF1) and early onset of extracolonic cancer.
Pubmed
12522551
Original source reporting the Gene Disease association
UNIPROT
DisGENET score for the Gene Disease association
0.670236158889378
Year of publication
2003
Drugs