Annotation Detail
Information
- Associated Genes
- BRCA1
- Associated Variants
-
WRN p.Cys1367Arg (p.C1367R)
(
ENST00000298139.7 )
WRN p.Cys1367Arg (p.C1367R) ( ENST00000298139.7 ) - Associated Disease
- Breast Cancer, Familial
- Source Database
- DisGeNET
- Description
- Genotyping analyses, performed on 816 BRCA1/2 mutation-negative German familial breast cancer patients and 1012 German controls, revealed a significant association of the WRN Cys1367Arg polymorphism with familial breast cancer (OR = 1.28, 95% CI 1.06-1.54) and high-risk familial breast cancer (OR = 1.32, 95% CI 1.06-1.65).
- Pubmed
- 16501249
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.195656337440284
- Year of publication
- 2006
Drugs