Annotation Detail
Information
- Associated Genes
- ZAP70
- Associated Variants
-
ZAP70 MUTATION
ZAP70 MUTATION - Associated Disease
- chronic lymphocytic leukemia
- Source Database
- DisGeNET
- Description
- Higher CD105 expression was significantly associated with unmutated IgVH genes (n = 55, p < 0.001), high CD38 expression (n = 66, p = 0.022), high ZAP-70 expression (n = 66, p = 0.010), Rai stage I-IV (n = 70, p < 0.001), progressive clinical course of CLL (n = 70, p = 0.001) and shorter time to treatment (n = 70; p < 0.001).
- Pubmed
- 25030442
- Section of the abstract supporting the evidence
- ALL_TEXT_2/3
- Number of the section of the abstract supporting the evidence
- 2
- Number of the sentence supporting the evidence
- 4
- Original source reporting the Gene Disease association
- BeFree,LHGDN
- DisGENET score for the Gene Disease association
- 0.0796615783011627
Drugs