Annotation Detail
Information
- Associated Genes
- STAT5A
- Associated Variants
-
STAT5A MUTATION
STAT5A MUTATION - Associated Disease
- leukemia
- Source Database
- DisGeNET
- Description
- Binding of the SH2 domain to the activation loop is required for STAT5A(Y694) phosphorylation by SFK, but at the same time promotes the persistent cytoplasmic localization of the transcription factor as found in BCR-ABL(+) leukemia.
- Pubmed
- 25885255
- Section of the abstract supporting the evidence
- RESULTS
- Number of the section of the abstract supporting the evidence
- 2
- Number of the sentence supporting the evidence
- 7
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00651460492992728
Drugs