Annotation Detail
Information
- Associated Genes
- IFNL3
- Associated Variants
-
IFNL4 c.151-152G>A
(
ENST00000606380.2 )
IFNL4 c.151-152G>A ( ENST00000606380.2 ) - Associated Disease
- Hepatitis C, Chronic
- Source Database
- DisGeNET
- Description
- The IL28B genotype is the most important pretreatment predictor of treatment outcome in patients with chronic hepatitis C. The impact of the rs12979860 genotype on relapse was retrospectively evaluated in genotype 1/4 patients who received response-guided therapy with peginterferon alpha-2a 180 μg/week plus ribavirin 1,000/1,200 mg/day in a large, randomized, multicenter study.
- Pubmed
- 22006276
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0948429671860937
- Year of publication
- 2011
Drugs