Annotation Detail
Information
- Associated Genes
- NOS3
- Associated Variants
-
NOS3 MUTATION
NOS3 MUTATION - Associated Disease
- ischemia
- Source Database
- DisGeNET
- Description
- Using high-frequency ultrasound, we visualized, quantified, and characterized for the first time endothelium-dependent dilation of the femoral artery after temporal ischemia of the lower part of the hindlimb and demonstrated that the signaling was almost exclusively dependent on stimulation of endothelial nitric oxide synthase, similar to acetylcholine, completely abolished after pharmacological or genetic inhibition of endothelial nitric oxide synthase and endothelial denudation, substantially impaired in mice of increasing age and cholesterol-fed ApoE knock outs and increased by the dietary polyphenol (-)-epicatechin.
- Pubmed
- 25341800
- Section of the abstract supporting the evidence
- APPROACH AND RESULTS
- Number of the section of the abstract supporting the evidence
- 2
- Number of the sentence supporting the evidence
- 3
- Original source reporting the Gene Disease association
- BeFree,CTD_human,GAD,LHGDN
- DisGENET score for the Gene Disease association
- 0.128077242813953
Drugs