Annotation Detail
Information
- Associated Genes
- DIO2
- Associated Variants
-
DIO2 p.Thr92Ala (p.T92A)
(
ENST00000557010.5,
ENST00000557125.1,
ENST00000438257.9 )
DIO2 c.-53-398G>C ( ENST00000557010.5 )
DIO2 c.-53-398G>A ( ENST00000557010.5 )
DIO2 p.Thr92Ala (p.T92A) ( ENST00000438257.9, ENST00000557010.5, ENST00000557125.1 )
DIO2 c.-53-398G>C ( ENST00000557010.5 )
DIO2 c.-53-398G>A ( ENST00000557010.5 ) - Associated Disease
- Osteoarthritis of hip
- Source Database
- DisGeNET
- Description
- Confirmation and replication by association in the additional osteoarthritis studies indicated a common DIO2 haplotype, exclusively containing the minor allele of rs225014 and common allele of rs12885300, with a combined recessive odds ratio of 1.79, 95% confidence interval (CI) 1.37-2.34 with P = 2.02 x 10(-5) in female cases with advanced/symptomatic hip osteoarthritis.
- Pubmed
- 18334578
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000542883744160607
- Year of publication
- 2008
Drugs