Annotation Detail
Information
- Associated Genes
- CXCR4
- Associated Variants
-
CXCL12 c.*519G>A
(
ENST00000395793.7,
ENST00000374429.6 )
CD4 c.215-814A>T ( ENST00000011653.9, ENST00000541982.5 )
CCR7 c.10+1853G>A ( ENST00000246657.2 )
CXCR4 p.Ile142= (p.I142=) ( ENST00000241393.4, ENST00000409817.1, ENST00000466288.1, ENST00000696136.1, ENST00000696137.1, ENST00000696152.1, ENST00000696228.1 )
VEGFA c.*237C>T ( ENST00000230480.10, ENST00000372064.9, ENST00000372067.8, ENST00000372077.8, ENST00000425836.9, ENST00000520948.5, ENST00000523950.5, ENST00000672860.3 )
CXCL12 c.*519G>A ( ENST00000374429.6, ENST00000395793.7 )
CD4 c.215-814A>T ( ENST00000011653.9, ENST00000541982.5 )
CCR7 c.10+1853G>A ( ENST00000246657.2 )
CXCR4 p.Ile142= (p.I142=) ( ENST00000241393.4, ENST00000409817.1, ENST00000466288.1, ENST00000696136.1, ENST00000696137.1, ENST00000696152.1, ENST00000696228.1 )
VEGFA c.*237C>T ( ENST00000230480.10, ENST00000372064.9, ENST00000372067.8, ENST00000372077.8, ENST00000425836.9, ENST00000520948.5, ENST00000523950.5, ENST00000672860.3 ) - Associated Disease
- Malignant neoplasm of breast
- Source Database
- DisGeNET
- Description
- Similarly, the SNP barcode of rs12812942-rs2228014-rs3025039 (CD4-CXCR4-VEGF) and rs12812942-rs3136685-rs2228014-rs1801157 (CD4- CCR7-CXCR4-CXCL12) with specific genotype patterns (AT-CC-CC and AT-AG-CC-GG) among three and four combinational SNPs were significantly low in breast cancer occurrence.
- Pubmed
- 19196101
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0289683354424718
- Year of publication
- 2009
Drugs