Annotation Detail
Information
- Associated Genes
- CRP
- Associated Variants
-
GCKR p.Leu446Pro (p.L446P)
(
ENST00000264717.7 )
GCKR c.1423-418T>C ( ENST00000264717.7 )
GCKR p.Leu446Pro (p.L446P) ( ENST00000264717.7 )
GCKR c.1423-418T>C ( ENST00000264717.7 ) - Associated Disease
- diabetes mellitus
- Source Database
- DisGeNET
- Description
- The intronic single-nucleotide polymorphism (SNP) rs780094 (intron 16) and the missense SNP rs1260326 (P446L) in the GCKR gene are strongly associated with increased circulating triglyceride and C-reactive protein levels and, paradoxically, reductions in diabetes incidence, fasting glucose levels, and insulin resistance.
- Pubmed
- 21525158
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0263933318968359
- Year of publication
- 2011
Drugs