Annotation Detail
Information
- Associated Genes
- GCKR
- Associated Variants
-
GCKR p.Leu446Pro (p.L446P)
(
ENST00000264717.7 )
GCKR c.1423-418T>C ( ENST00000264717.7 )
GCKR p.Leu446Pro (p.L446P) ( ENST00000264717.7 )
GCKR c.1423-418T>C ( ENST00000264717.7 ) - Associated Disease
- Diabetes Mellitus, Non-Insulin-Dependent
- Source Database
- DisGeNET
- Description
- Recently, the association of the natural variants rs1260326 and rs780094 of the glucokinase regulatory protein (GCKR) gene with increased fasting triglycerides and decreased fasting plasma glucose in diabetic adults was reported; the minor alleles were also found to reduce the risk of type 2 diabetes.
- Pubmed
- 21511510
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.162020084608958
- Year of publication
- 2011
Drugs