Annotation Detail
Information
- Associated Genes
- AKR1A1
- Associated Variants
-
ADH1B p.His48Arg (p.H48R)
(
ENST00000305046.13,
ENST00000506651.5,
ENST00000625860.2 )
ADH1B p.His48Arg (p.H48R) ( ENST00000305046.13, ENST00000506651.5, ENST00000625860.2 ) - Associated Disease
- Alcoholic Intoxication, Chronic
- Source Database
- DisGeNET
- Description
- Because alcohol dehydrogenase (ADH1B) His47Arg and mitochondrial aldehyde dehydrogenase (ALDH2) Glu487Lys single nucleotide polymorphisms (SNPs), which affect alcohol metabolism, have been reported to exert significant impacts on alcohol consumption and on the risk for alcoholism in East Asia populations, we explored associations of the two functional SNPs with suicide using a case-control study of 283 completed suicides and 319 control subjects in the Japanese population.
- Pubmed
- 20180859
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.015200744836497
- Year of publication
- 2010
Drugs