Annotation Detail
Information
- Associated Genes
- AKR1B1
- Associated Variants
-
AKR1B1 MUTATION
AKR1B1 MUTATION - Associated Disease
- hyperglycemia
- Source Database
- DisGeNET
- Description
- These results indicate that high AR expression in the context of hyperglycemia and insulin deficiency may constitute a risk factor that could predispose the lens to disturbances in signaling through the ERK and JNK pathways and thereby alter the balance of cell growth and apoptosis that is critical to lens transparency and homeostasis.
- Pubmed
- 25541468
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 11
- Original source reporting the Gene Disease association
- BeFree,RGD
- DisGENET score for the Gene Disease association
- 0.0832573024649636
Drugs