Annotation Detail
Information
- Associated Genes
- XRCC6P5
- Associated Variants
-
MGMT c.-12-9206C>T
(
ENST00000651593.1,
ENST00000306010.8 )
MGMT p.Lys178Arg (p.K178R) ( ENST00000306010.8, ENST00000651593.1 )
MGMT c.-12-9206C>T ( ENST00000306010.8, ENST00000651593.1 )
MGMT p.Lys178Arg (p.K178R) ( ENST00000306010.8, ENST00000651593.1 ) - Associated Disease
- Malignant neoplasm of lung
- Source Database
- DisGeNET
- Description
- The association between lung cancer risk and 2 polymorphisms, rs12268840 and rs2308327 (codon K178R), in the DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase, which are associated with interindividual differences in activity, have been investigated in 3 hospital-based case-control studies.
- Pubmed
- 17957803
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000542883744160607
- Year of publication
- 2008
Drugs