Annotation Detail
Information
- Associated Genes
- SOD2
- Associated Variants
-
SOD1 c.169+622_169+624delAGA
(
ENST00000270142.11,
ENST00000389995.4 )
SOD1 c.169+622_169+624delAGA ( ENST00000270142.11, ENST00000389995.4 )
SOD1 c.169+192T>G ( ENST00000270142.11, ENST00000389995.4 )
SOD1 c.357+341A>G ( ENST00000270142.11, ENST00000389995.4 )
SOD2 c.523+1042C>A ( ENST00000337404.8, ENST00000367054.6, ENST00000367055.8, ENST00000444946.6, ENST00000538183.7, ENST00000546087.5 )
SOD2 c.343+733T>C ( ENST00000337404.8, ENST00000367054.6, ENST00000367055.8, ENST00000444946.6, ENST00000538183.7, ENST00000546087.5 )
SOD1 c.169+192T>G ( ENST00000270142.11, ENST00000389995.4 )
SOD1 c.357+341A>G ( ENST00000270142.11, ENST00000389995.4 )
SOD2 c.523+1042C>A ( ENST00000337404.8, ENST00000367054.6, ENST00000367055.8, ENST00000444946.6, ENST00000538183.7, ENST00000546087.5 )
SOD2 c.343+733T>C ( ENST00000337404.8, ENST00000367054.6, ENST00000367055.8, ENST00000444946.6, ENST00000538183.7, ENST00000546087.5 ) - Associated Disease
- Malignant neoplasm of prostate
- Source Database
- DisGeNET
- Description
- Two variants in SOD2 were significantly associated with the risk of aggressive prostate cancer (rs17884057, odds ratio 0.83, 95% confidence interval 0.70-0.99; and rs4816407, 1.27, 1.02-1.57); men with A alleles at rs2842958 in SOD2 had lower plasma selenium levels (median 116 vs 121.8 µg/L, P= 0.03); and the association between plasma selenium levels and risk of aggressive prostate cancer was modified by SOD1 (rs10432782) and SOD2 (rs2758330).
- Pubmed
- 20477822
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0448540554615997
- Year of publication
- 2011
Drugs