Annotation Detail

Information
Associated Genes
PGR
Associated Variants
PGR p.Val660Leu (p.V660L) ( ENST00000534013.5, ENST00000263463.9, ENST00000619228.2, ENST00000325455.10 )
ESR1 c.453-397T>C ( ENST00000206249.8, ENST00000338799.9, ENST00000406599.5, ENST00000427531.6, ENST00000440973.5, ENST00000443427.5, ENST00000456483.3 )
ESR1 p.Pro325= (p.P325=) ( ENST00000206249.8, ENST00000338799.9, ENST00000406599.5, ENST00000427531.6, ENST00000456483.3, ENST00000440973.5, ENST00000443427.5 )
PGR p.Val660Leu (p.V660L) ( ENST00000263463.9, ENST00000325455.10, ENST00000534013.5, ENST00000619228.2 )
ESR1 c.453-397T>C ( ENST00000206249.8, ENST00000338799.9, ENST00000406599.5, ENST00000427531.6, ENST00000440973.5, ENST00000443427.5, ENST00000456483.3 )
ESR1 p.Pro325= (p.P325=) ( ENST00000206249.8, ENST00000338799.9, ENST00000406599.5, ENST00000427531.6, ENST00000440973.5, ENST00000443427.5, ENST00000456483.3 )
Associated Disease
Tension Headache
Source Database
DisGeNET
Description
We aimed to explore the single-locus, haplotype and epistasis patterns and the contribution of oestrogen receptor [ESR1 PvuII (rs2234693), ESR1 325 C→G (rs1801132)] and progesterone receptor [PROGINS (rs1042838)] polymorphisms in genetic susceptibility to migraine by analysing 613 subjects consisting of 217 migraine patients, 217 healthy controls (HC) and 179 patients with tension-type headache (TTH).
Pubmed
19673915
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.000271441872080303
Year of publication
2010
Drugs