Annotation Detail
Information
- Associated Genes
- FLT3
- Associated Variants
-
FLT3 p.Asp835Tyr (p.D835Y)
(
ENST00000241453.12 )
FLT3 p.Asp835His (p.D835H) ( ENST00000241453.12 )
FLT3 p.Asp835Asn (p.D835N) ( ENST00000241453.12 )
FLT3 p.Asp835Tyr (p.D835Y) ( ENST00000241453.12 )
FLT3 p.Asp835His (p.D835H) ( ENST00000241453.12 )
FLT3 p.Asp835Asn (p.D835N) ( ENST00000241453.12 ) - Associated Disease
- Leukemia, Myelocytic, Acute
- Source Database
- DisGeNET
- Description
- Our FLT3-Aurora kinase inhibitor, CCT137690, successfully inhibited growth of FLT3-ITD-D835Y cells in vitro and in vivo, suggesting that dual FLT3-Aurora inhibition may overcome selective FLT3 inhibitor resistance, in part due to inhibition of Aurora kinase, and may benefit patients with FLT3-mutated AML.
- Pubmed
- 22354205
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.56
- Year of publication
- 2012
Drugs