Annotation Detail
Information
- Associated Genes
- HSP90AA1
- Associated Variants
-
ABL1 p.Thr334Ile (p.T334I)
(
ENST00000372348.9,
ENST00000318560.6 )
ABL1 p.Thr334Ile (p.T334I) ( ENST00000372348.9, ENST00000318560.6 ) - Associated Disease
- leukemia
- Source Database
- DisGeNET
- Description
- We recently showed that inhibition of heat shock protein 90 (Hsp90) by a novel Hsp90 inhibitor, IPI- 504, causes BCR-ABL protein degradation, decreased numbers of leukemia stem cells, and prolonged survival of mice with CML induced by BCR-ABL-T315I.
- Pubmed
- 17671436
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00380018620912425
- Year of publication
- 2007
Drugs