Annotation Detail
Information
- Associated Genes
- ABL1
- Associated Variants
-
ABL1 p.Glu255Lys (p.E255K)
(
ENST00000318560.6,
ENST00000372348.9 )
ABL1 p.Glu274Lys (p.E274K) ( ENST00000318560.6, ENST00000372348.9 )
ABL1 p.Glu255Lys (p.E255K) ( ENST00000318560.6, ENST00000372348.9 )
ABL1 p.Glu274Lys (p.E274K) ( ENST00000318560.6, ENST00000372348.9 ) - Associated Disease
- Myeloid Leukemia, Chronic
- Source Database
- DisGeNET
- Description
- Rottlerin also enhanced the cytotoxic effect of imatinib in leukemic cells from patients with CML blast crisis and Ph-positive ALL or a cell line expressing the imatinib-resistant E255K BCR/ABL mutant.
- Pubmed
- 17130834
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.371405336343011
- Year of publication
- 2007
Drugs