Annotation Detail
Information
- Associated Genes
- ITGB2
- Associated Variants
-
NRAS p.Gly12Val (p.G12V)
(
ENST00000369535.5 )
NRAS p.Gly12Ala (p.G12A) ( ENST00000369535.5 )
NRAS p.Gly12Asp (p.G12D) ( ENST00000369535.5 )
NRAS p.Gly12Val (p.G12V) ( ENST00000369535.5 )
NRAS p.Gly12Ala (p.G12A) ( ENST00000369535.5 )
NRAS p.Gly12Asp (p.G12D) ( ENST00000369535.5 ) - Associated Disease
- leukemia
- Source Database
- DisGeNET
- Description
- In a multiplexed analysis of RAS-dependent signaling, Mac-1(Low) cells, which harbor leukemia stem cells, were preferentially sensitive to NRAS(G12V) withdrawal.
- Pubmed
- 25316678
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00081432561624091
- Year of publication
- 2015
Drugs