Annotation Detail
Information
- Associated Genes
- ABL1
- Associated Variants
-
NRAS p.Gly12Val (p.G12V)
(
ENST00000369535.5 )
NRAS p.Gly12Ala (p.G12A) ( ENST00000369535.5 )
NRAS p.Gly12Asp (p.G12D) ( ENST00000369535.5 )
NRAS p.Gly12Val (p.G12V) ( ENST00000369535.5 )
NRAS p.Gly12Ala (p.G12A) ( ENST00000369535.5 )
NRAS p.Gly12Asp (p.G12D) ( ENST00000369535.5 ) - Associated Disease
- Pre B-cell acute lymphoblastic leukemia
- Source Database
- DisGeNET
- Description
- Inducible, Cre-mediated deletion of Hspa5, Prdm1, and Xbp1 consistently induces cellular stress and cell death in normal pre-B cells and in pre-B-cell acute lymphoblastic leukemia (ALL) driven by BCR-ABL1- and NRAS(G12D) oncogenes.
- Pubmed
- 24821775
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00135720936040152
- Year of publication
- 2014
Drugs