Annotation Detail

Information
Associated Genes
TP53
Associated Variants
TP53 p.Arg337Leu (p.R337L) ( ENST00000413465.6, ENST00000504937.5, ENST00000455263.6, ENST00000269305.9, ENST00000420246.6, ENST00000359597.8, ENST00000445888.6, ENST00000576024.2, ENST00000510385.5, ENST00000604348.6, ENST00000504290.5, ENST00000714409.1, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1 )
TP53 p.Arg337Pro (p.R337P) ( ENST00000445888.6, ENST00000420246.6, ENST00000359597.8, ENST00000504937.5, ENST00000576024.2, ENST00000269305.9, ENST00000455263.6, ENST00000510385.5, ENST00000413465.6, ENST00000604348.6, ENST00000504290.5, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 )
TP53 p.Arg337His (p.R337H) ( ENST00000504290.5, ENST00000510385.5, ENST00000455263.6, ENST00000269305.9, ENST00000413465.6, ENST00000604348.6, ENST00000359597.8, ENST00000445888.6, ENST00000420246.6, ENST00000576024.2, ENST00000504937.5, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1 )
TP53 p.Arg337Leu (p.R337L) ( ENST00000269305.9, ENST00000359597.8, ENST00000413465.6, ENST00000420246.6, ENST00000445888.6, ENST00000455263.6, ENST00000504290.5, ENST00000504937.5, ENST00000510385.5, ENST00000576024.2, ENST00000604348.6, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 )
TP53 p.Arg337Pro (p.R337P) ( ENST00000269305.9, ENST00000359597.8, ENST00000413465.6, ENST00000420246.6, ENST00000445888.6, ENST00000604348.6, ENST00000455263.6, ENST00000504290.5, ENST00000504937.5, ENST00000510385.5, ENST00000576024.2, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 )
TP53 p.Arg337His (p.R337H) ( ENST00000269305.9, ENST00000359597.8, ENST00000413465.6, ENST00000420246.6, ENST00000445888.6, ENST00000455263.6, ENST00000504290.5, ENST00000504937.5, ENST00000510385.5, ENST00000576024.2, ENST00000604348.6, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 )
Associated Disease
Agenesis of corpus callosum
Source Database
DisGeNET
Description
These results demonstrate a pH-sensitive molecular defect of p53 (R337H), suggesting that pH-dependent p53 dysfunction is the molecular basis for these cases of ACC in Brazilian children.
Pubmed
11753428
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.00732893054616819
Year of publication
2002
Drugs