Annotation Detail

Information
Associated Genes
COMT
Associated Variants
SULT2B1 c.215-2819T>C ( ENST00000201586.7, ENST00000323090.4 )
SULT2B1 c.423+1736A>G ( ENST00000201586.7, ENST00000323090.4 )
SULT2B1 c.646-1246A>G ( ENST00000201586.7, ENST00000323090.4 )
SULT2B1 c.646-1246A>T ( ENST00000201586.7, ENST00000323090.4 )
COMT c.-921-780C>A ( ENST00000361682.11, ENST00000403184.5, ENST00000403710.5, ENST00000406520.7, ENST00000407537.5, ENST00000428707.2, ENST00000676678.1, ENST00000678255.1, ENST00000678769.1, ENST00000678868.1 )
CYP1B1 p.Asn453Ser (p.N453S) ( ENST00000490576.2, ENST00000494864.1, ENST00000610745.5, ENST00000614273.1, ENST00000714520.1 )
CYP1B1 p.Asn453Thr (p.N453T) ( ENST00000490576.2, ENST00000494864.1, ENST00000610745.5, ENST00000614273.1, ENST00000714520.1 )
SULT2B1 c.215-2819T>C ( ENST00000201586.7, ENST00000323090.4 )
SULT2B1 c.423+1736A>G ( ENST00000201586.7, ENST00000323090.4 )
SULT2B1 c.646-1246A>G ( ENST00000201586.7, ENST00000323090.4 )
SULT2B1 c.646-1246A>T ( ENST00000201586.7, ENST00000323090.4 )
COMT c.-921-780C>A ( ENST00000361682.11, ENST00000403184.5, ENST00000403710.5, ENST00000406520.7, ENST00000407537.5, ENST00000428707.2, ENST00000676678.1, ENST00000678255.1, ENST00000678769.1, ENST00000678868.1 )
CYP1B1 p.Asn453Ser (p.N453S) ( ENST00000490576.2, ENST00000494864.1, ENST00000610745.5, ENST00000614273.1, ENST00000714520.1 )
CYP1B1 p.Asn453Thr (p.N453T) ( ENST00000490576.2, ENST00000494864.1, ENST00000610745.5, ENST00000614273.1, ENST00000714520.1 )
Associated Disease
prostate carcinoma
Source Database
DisGeNET
Description
According to a multivariate analysis, CYP1B1 (rs1800440), COMT (rs16982844), and SULT2B1 (rs12460535, rs2665582, rs10426628) were significantly associated with prostate cancer progression and hormone levels.
Pubmed
24682418
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.00508145069940506
Year of publication
2015
Drugs