Annotation Detail
Information
- Associated Genes
- IRS2
- Associated Variants
-
IRS2 MUTATION
IRS2 MUTATION - Associated Disease
- diabetes mellitus
- Source Database
- DisGeNET
- Description
- The best evidence of this is that systemic elimination of the Irs2 in mice (Irs2(-/-)) recapitulates the pathogenesis of type 2 diabetes (T2D), in that diabetes arises as a consequence of combined insulin resistance and beta-cell failure.
- Pubmed
- 24977713
- Section of the abstract supporting the evidence
- ALL_TEXT_2/3
- Number of the section of the abstract supporting the evidence
- 2
- Number of the sentence supporting the evidence
- 3
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00515739556952576
Drugs