Annotation Detail
Information
- Associated Genes
- PON2
- Associated Variants
-
PON2 p.Ser311Cys (p.S311C)
(
ENST00000222572.8,
ENST00000433091.6,
ENST00000633192.1,
ENST00000633531.1 )
PON2 p.Ala148Gly (p.A148G) ( ENST00000222572.8, ENST00000433091.6, ENST00000633192.1, ENST00000633531.1 )
PON2 c.75-110A>C ( ENST00000222572.8, ENST00000433091.6, ENST00000633192.1, ENST00000633531.1 )
PON2 p.Ser311Cys (p.S311C) ( ENST00000222572.8, ENST00000433091.6, ENST00000633192.1, ENST00000633531.1 )
PON2 p.Ala148Gly (p.A148G) ( ENST00000222572.8, ENST00000433091.6, ENST00000633192.1, ENST00000633531.1 )
PON2 c.75-110A>C ( ENST00000222572.8, ENST00000433091.6, ENST00000633192.1, ENST00000633531.1 ) - Associated Disease
- diabetes mellitus
- Source Database
- DisGeNET
- Description
- We examined the relationship between variation at the C311S and A148G polymorphisms (together with PON2 intronic variant rs12704795) and indices of renal dysfunction (progression to micro- and macroalbuminuria, plasma creatinine increases) in 3,374 newly diagnosed type 2 diabetic subjects from the UK Prospective Diabetes Study followed prospectively (median 14.0 years), using proportional hazards models, adjusted for sex, ethnicity and other known or putative risk factors.
- Pubmed
- 17096118
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00162865123248182
- Year of publication
- 2006
Drugs