Annotation Detail
Information
- Associated Genes
- APOC3
- Associated Variants
-
APOC3 MUTATION
APOC3 MUTATION - Associated Disease
- Coronary heart disease
- Source Database
- DisGeNET
- Description
- Furthermore, identification of rare loss-of-function variants in genes such as PCSK9, NPC1L1, APOC3 and APOA5, which cause a markedly decreased risk of CHD and no adverse side effects, illustrates the power of translating genetic findings into novel mechanistic information and provides some optimism for the future of developing novel drugs, given the many genes associated with CHD in GWASs.
- Pubmed
- 26477595
- Section of the abstract supporting the evidence
- ALL_TEXT_2/3
- Number of the section of the abstract supporting the evidence
- 2
- Number of the sentence supporting the evidence
- 4
- Original source reporting the Gene Disease association
- BeFree,CLINVAR,GAD,LHGDN
- DisGENET score for the Gene Disease association
- 0.143798465307872
Drugs