Annotation Detail
Information
- Associated Genes
- UGT1A1
- Associated Variants
-
UGT1A8 c.855+38075A>C, UGT1A10 c.855+19260A>C
(
ENST00000344644.10,
ENST00000373445.1,
ENST00000373450.5 )
TACC3 c.1591+1211T>C ( ENST00000313288.9, ENST00000651472.1, ENST00000652770.1 )
UGT1A8 c.855+38075A>C, UGT1A10 c.855+19260A>C ( ENST00000344644.10, ENST00000373445.1, ENST00000373450.5 )
TACC3 c.1591+1211T>C ( ENST00000313288.9, ENST00000651472.1, ENST00000652770.1 ) - Associated Disease
- Malignant neoplasm of urinary bladder
- Source Database
- DisGeNET
- Description
- Using data on high-risk occupations for 2258 case patients and 2410 control patients from two bladder cancer studies, we observed that three of 16 known or candidate bladder cancer susceptibility variants displayed statistically significant and consistent evidence of additive interactions; specifically, the GSTM1 deletion polymorphism (P interaction ≤ .001), rs11892031 (UGT1A, P interaction = .01), and rs798766 (TMEM129-TACC3-FGFR3, P interaction = .03).
- Pubmed
- 26374428
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00135720936040152
- Year of publication
- 2015
Drugs