Annotation Detail
Information
- Associated Genes
- KCNJ11
- Associated Variants
-
CNNM1 c.2403+2206G>A
(
ENST00000356713.5,
ENST00000696687.1 )
KCNJ11 p.Leu270Val (p.L270V) ( ENST00000339994.5, ENST00000682350.1, ENST00000682764.1, ENST00000528731.1 )
KCNJ11 p.Leu270Met (p.L270M) ( ENST00000528731.1, ENST00000682764.1, ENST00000682350.1, ENST00000339994.5 )
SLC41A1 c.1357-1560G>A ( ENST00000367137.4 )
rs11590362
rs5930817
rs5929706
CNNM1 c.2403+2206G>A ( ENST00000356713.5, ENST00000696687.1 )
KCNJ11 p.Leu270Val (p.L270V) ( ENST00000339994.5, ENST00000528731.1, ENST00000682350.1, ENST00000682764.1 )
KCNJ11 p.Leu270Met (p.L270M) ( ENST00000339994.5, ENST00000528731.1, ENST00000682350.1, ENST00000682764.1 )
SLC41A1 c.1357-1560G>A ( ENST00000367137.4 )
rs11590362
rs5930817
rs5929706 - Associated Disease
- Diabetes Mellitus, Non-Insulin-Dependent
- Source Database
- DisGeNET
- Description
- Among women with magnesium intake in the lowest 30% (AA: ≤0.164 g/d; HA: ≤0.185 g/d), 4 SNP signals were strengthened [rs11590362 in claudin 19 (CLDN19), rs823154 in SLC41A1, rs5929706 and rs5930817 in membra; HA: ≥0.313 g/d), rs6584273 in CNNM1 (OR: 0.71; FDR-adjusted P = 0.04) and rs1800467 in potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11) (OR: 2.50; FDR-adjusted P = 0.01) were significantly associated with T2D risk.
- Pubmed
- 25733456
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.465515535975549
- Year of publication
- 2015
Drugs