Annotation Detail
Information
- Associated Genes
- IL1A
- Associated Variants
-
rs2234650
(
ENST00000409329.5,
ENST00000409589.5,
ENST00000409929.5,
ENST00000424272.5 )
rs1800587
IL1B SNV
IL1B p.Phe105= (p.F105=) ( ENST00000263341.7 )
NC_000002.12:g.112837290A>G
rs2234650 ( ENST00000409329.5, ENST00000409589.5, ENST00000409929.5, ENST00000424272.5 )
rs1800587
IL1B SNV
IL1B p.Phe105= (p.F105=) ( ENST00000263341.7 )
NC_000002.12:g.112837290A>G - Associated Disease
- ankylosing spondylitis
- Source Database
- DisGeNET
- Description
- Polymorphisms of IL1α rs1800587, IL1β rs16944 and IL1β rs1143634 were not significantly associated with ankylosing spondylitis but inversely in this study IL1R rs2234650 was significantly associated and carriage of T allele in IL1R rs2234650 seems to be protective, while carriage of C allele result in two fold higher risk of developing AS.
- Pubmed
- 22285486
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0151684072280945
- Year of publication
- 2011
Drugs