Annotation Detail
Information
- Associated Genes
- IL1RN
- Associated Variants
-
IL1B c.-118C>T
NC_000002.12:g.112837290A>G
IL1RN p.Ala60= (p.A60=) ( ENST00000259206.9, ENST00000354115.6, ENST00000361779.7, ENST00000409930.4, ENST00000696879.1, ENST00000696881.1 )
IL1B c.-118C>T
NC_000002.12:g.112837290A>G
IL1RN p.Ala60= (p.A60=) ( ENST00000259206.9, ENST00000354115.6, ENST00000361779.7, ENST00000409930.4, ENST00000696879.1, ENST00000696881.1 ) - Associated Disease
- Degenerative polyarthritis
- Source Database
- DisGeNET
- Description
- A 3-single-nucleotide polymorphism (SNP) IL1B-IL1RN haplotype rs1143627-rs16944-rs419598 showed a trend toward hand OA association (posterior probability of association 0.72) with the most prominent feature being protection from a specific haplotype representing a partial mirror image of the extended risk haplotype (OR estimated at 0.46).
- Pubmed
- 19733643
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0258081790226087
- Year of publication
- 2010
Drugs