Annotation Detail

Information
Associated Genes
MLH1
Associated Variants
MLH1 p.Glu23Lys (p.E23K) ( ENST00000231790.8, ENST00000450420.6, ENST00000456676.7, ENST00000536378.5, ENST00000616768.6, ENST00000673673.2, ENST00000673715.1, ENST00000673899.1, ENST00000713802.1 )
MLH1 p.Glu23Lys (p.E23K) ( ENST00000231790.8, ENST00000450420.6, ENST00000456676.7, ENST00000536378.5, ENST00000616768.6, ENST00000673673.2, ENST00000673715.1, ENST00000673899.1, ENST00000713802.1 )
Associated Disease
Hereditary cancer-predisposing syndrome
Source Database
ClinVar
Description
NM_000249.4(MLH1):c.67G>A (p.Glu23Lys) AND Hereditary cancer-predisposing syndrome
ClinVar Allele ID
95804
ClinVar RefSeq Alternation Syntax
NM_001354615.2:c.-560G>A
ClinVar RefSeq Alternation Syntax
NM_001354622.2:c.-1090G>A
ClinVar RefSeq Alternation Syntax
NM_001354616.2:c.-560G>A
ClinVar RefSeq Alternation Syntax
NM_001167618.3:c.-879G>A
ClinVar RefSeq Alternation Syntax
NM_001167619.3:c.-792G>A
ClinVar RefSeq Alternation Syntax
NM_001167617.3:c.-450G>A
ClinVar RefSeq Alternation Syntax
NM_001354621.2:c.-977G>A
ClinVar RefSeq Alternation Syntax
NM_001354626.2:c.-755G>A
ClinVar RefSeq Alternation Syntax
NM_001354623.2:c.-999G>A
ClinVar RefSeq Alternation Syntax
NM_000249.4:c.67G>A
ClinVar RefSeq Alternation Syntax
NM_001258274.3:c.-1029G>A
ClinVar RefSeq Alternation Syntax
NM_001354627.2:c.-987G>A
ClinVar RefSeq Alternation Syntax
NM_001354617.2:c.-652G>A
ClinVar RefSeq Alternation Syntax
NM_001258271.2:c.67G>A
ClinVar RefSeq Alternation Syntax
NM_001354619.2:c.-1008G>A
ClinVar RefSeq Alternation Syntax
NM_001354628.2:c.67G>A
ClinVar RefSeq Alternation Syntax
NM_001354618.2:c.-884G>A
ClinVar RefSeq Alternation Syntax
NM_001354624.2:c.-760G>A
ClinVar RefSeq Alternation Syntax
NM_001354630.2:c.67G>A
ClinVar RefSeq Alternation Syntax
NM_001258273.2:c.-566G>A
ClinVar RefSeq Alternation Syntax
NM_001354620.2:c.-218G>A
ClinVar RefSeq Alternation Syntax
NM_001354625.2:c.-658G>A
ClinVar RefSeq Alternation Syntax
NM_001354629.2:c.67G>A
Clinical Significance Description
Uncertain significance
Clinical Significance Last Update
2021-12-28
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV004019105
ClinVar Disease
Hereditary cancer-predisposing syndrome
Observed Origin Sample
germline
Drugs