Annotation Detail

Information
Associated Genes
ARSA
Associated Variants
ARSA p.Arg246Cys (p.R246C) ( ENST00000216124.10, ENST00000356098.9, ENST00000395619.3, ENST00000395621.7, ENST00000453344.6 )
ARSA p.Arg246Cys (p.R246C) ( ENST00000216124.10, ENST00000356098.9, ENST00000395619.3, ENST00000395621.7, ENST00000453344.6 )
Associated Disease
Metachromatic leukodystrophy, juvenile type
Source Database
ClinVar
Description
NM_000487.6(ARSA):c.736C>T (p.Arg246Cys) AND Metachromatic leukodystrophy, juvenile type
ClinVar Allele ID
18112
ClinVar RefSeq Alternation Syntax
NM_001362782.2:c.478C>T
ClinVar RefSeq Alternation Syntax
NM_001085427.3:c.736C>T
ClinVar RefSeq Alternation Syntax
NM_001085428.3:c.478C>T
ClinVar RefSeq Alternation Syntax
NM_001085425.3:c.736C>T
ClinVar RefSeq Alternation Syntax
NM_000487.6:c.736C>T
ClinVar RefSeq Alternation Syntax
NM_001085426.3:c.736C>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2022-12-23
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV003993733
ClinVar Disease
Metachromatic leukodystrophy, juvenile type
Observed Origin Sample
germline
Drugs