Annotation Detail

Information
Associated Genes
SMPD1
Associated Variants
SMPD1 p.Arg498Cys (p.R498C) ( ENST00000527275.5, ENST00000342245.9 )
SMPD1 p.Arg498Cys (p.R498C) ( ENST00000342245.9, ENST00000527275.5 )
Associated Disease
SMPD1-related disorder
Source Database
ClinVar
Description
NM_000543.5(SMPD1):c.1492C>T (p.Arg498Cys) AND SMPD1-related disorder
ClinVar Allele ID
195256
ClinVar RefSeq Alternation Syntax
NM_001365135.2:c.1360C>T
ClinVar RefSeq Alternation Syntax
NM_000543.5:c.1492C>T
ClinVar RefSeq Alternation Syntax
NR_134502.2:n.984C>T
ClinVar RefSeq Alternation Syntax
NM_001318088.2:c.571C>T
ClinVar RefSeq Alternation Syntax
NR_027400.3:n.1445C>T
ClinVar RefSeq Alternation Syntax
NM_001007593.3:c.1489C>T
ClinVar RefSeq Alternation Syntax
NM_001318087.2:c.1512C>T
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2023-10-23
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV003955080
ClinVar Disease
SMPD1-related disorder
Observed Origin Sample
germline
Drugs