Annotation Detail

Information
Associated Genes
SMPD1
Associated Variants
SMPD1 p.Arg476Trp (p.R476W) ( ENST00000527275.5, ENST00000342245.9 )
SMPD1 p.Arg476Trp (p.R476W) ( ENST00000342245.9, ENST00000527275.5 )
Associated Disease
SMPD1-related disorder
Source Database
ClinVar
Description
NM_000543.5(SMPD1):c.1426C>T (p.Arg476Trp) AND SMPD1-related disorder
ClinVar Allele ID
99222
ClinVar RefSeq Alternation Syntax
NM_001007593.3:c.1423C>T
ClinVar RefSeq Alternation Syntax
NR_027400.3:n.1379C>T
ClinVar RefSeq Alternation Syntax
NM_001318087.2:c.1426C>T
ClinVar RefSeq Alternation Syntax
NM_001318088.2:c.505C>T
ClinVar RefSeq Alternation Syntax
NM_000543.5:c.1426C>T
ClinVar RefSeq Alternation Syntax
NM_001365135.2:c.1294C>T
ClinVar RefSeq Alternation Syntax
NR_134502.2:n.898C>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2024-01-26
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV003925040
ClinVar Disease
SMPD1-related disorder
Observed Origin Sample
germline
Drugs