Annotation Detail

Information
Associated Genes
NF1 MIR4733HG LOC111811965
Associated Variants
NF1 p.Glu19Ter (p.E19*) ( ENST00000696138.1, ENST00000358273.9, ENST00000691014.1, ENST00000356175.7, ENST00000431387.8, ENST00000487476.5 )
NF1 p.Glu19Ter (p.E19*) ( ENST00000356175.7, ENST00000358273.9, ENST00000431387.8, ENST00000487476.5, ENST00000691014.1, ENST00000696138.1 )
Associated Disease
Neurofibromatosis, familial spinal neurofibromatosis-Noonan syndrome Café-au-lait macules with pulmonary stenosis juvenile myelomonocytic leukemia Neurofibromatosis, type 1
Source Database
ClinVar
Description
NM_001042492.3(NF1):c.55G>T (p.Glu19Ter) AND multiple conditions
ClinVar Allele ID
184496
ClinVar RefSeq Alternation Syntax
NM_001128147.3:c.55G>T
ClinVar RefSeq Alternation Syntax
NM_001042492.3:c.55G>T
ClinVar RefSeq Alternation Syntax
NM_000267.3:c.55G>T
Clinical Significance Description
Pathogenic
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV003883138
ClinVar Disease
Neurofibromatosis-Noonan syndrome
ClinVar Disease
Neurofibromatosis, type 1
ClinVar Disease
Café-au-lait macules with pulmonary stenosis
ClinVar Disease
Juvenile myelomonocytic leukemia
ClinVar Disease
Neurofibromatosis, familial spinal
Observed Origin Sample
paternal
Drugs