Annotation Detail

Information
Associated Genes
GLB1
Associated Variants
GLB1 c.457+2T>C ( ENST00000307363.10, ENST00000307377.12, ENST00000399402.7 )
GLB1 c.457+2T>C ( ENST00000307363.10, ENST00000307377.12, ENST00000399402.7 )
Associated Disease
GM1 gangliosidosis Mucopolysaccharidosis, MPS-IV-B
Source Database
ClinVar
Description
NM_000404.4(GLB1):c.457+2T>C AND multiple conditions
ClinVar Allele ID
98815
ClinVar RefSeq Alternation Syntax
NM_000404.4:c.457+2T>C
ClinVar RefSeq Alternation Syntax
NM_001317040.2:c.601+2T>C
ClinVar RefSeq Alternation Syntax
NM_001393580.1:c.457+2T>C
ClinVar RefSeq Alternation Syntax
NM_001135602.3:c.246-2671T>C
ClinVar RefSeq Alternation Syntax
NM_001079811.3:c.367+2T>C
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2023-09-06
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV003764757
ClinVar Disease
Mucopolysaccharidosis, MPS-IV-B
ClinVar Disease
GM1 gangliosidosis
Observed Origin Sample
germline
Drugs