Annotation Detail

Information
Associated Genes
RYR1 LOC126862902
Associated Variants
RYR1 p.Ile2781ArgfsTer49 (p.I2781Rfs*49) ( ENST00000355481.8, ENST00000359596.8, ENST00000689936.2, ENST00000713952.1, ENST00000713953.1 )
RYR1 p.Ile2781ArgfsTer49 (p.I2781Rfs*49) ( ENST00000355481.8, ENST00000359596.8, ENST00000689936.2, ENST00000713952.1, ENST00000713953.1 )
Associated Disease
Malignant hyperthermia, susceptibility to, 1
Source Database
ClinVar
Description
NM_000540.3(RYR1):c.8342_8343del (p.Ile2781fs) AND Malignant hyperthermia, susceptibility to, 1
ClinVar Allele ID
581552
ClinVar RefSeq Alternation Syntax
NM_001042723.2:c.8342_8343del
ClinVar RefSeq Alternation Syntax
NM_000540.3:c.8342_8343del
Clinical Significance Description
Uncertain significance
Clinical Significance Last Update
2023-03-30
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV003514405
ClinVar Disease
Malignant hyperthermia, susceptibility to, 1
Observed Origin Sample
germline
Drugs