Annotation Detail

Information
Associated Genes
LDLR
Associated Variants
LDLR p.Ter861CysfsTer69 (p.*861Cfs*69) ( ENST00000252444.10, ENST00000455727.6, ENST00000535915.5, ENST00000545707.5, ENST00000557933.5, ENST00000558013.5, ENST00000558518.6, ENST00000560467.2 )
LDLR p.Ter861CysfsTer69 (p.*861Cfs*69) ( ENST00000252444.10, ENST00000455727.6, ENST00000535915.5, ENST00000545707.5, ENST00000557933.5, ENST00000558013.5, ENST00000558518.6, ENST00000560467.2 )
Associated Disease
LDLR-related disorder
Source Database
ClinVar
Description
NM_000527.5(LDLR):c.2583_*4del (p.Ter861CysextTer?) AND LDLR-related disorder
Observed Origin Sample
germline
ClinVar Allele ID
2799541
ClinVar RefSeq Alternation Syntax
NM_001195798.2:c.2577_*4del
ClinVar RefSeq Alternation Syntax
NM_001195803.2:c.2049_*4del
ClinVar RefSeq Alternation Syntax
NM_001195800.2:c.2079_*4del
ClinVar RefSeq Alternation Syntax
NM_000527.5:c.2583_*4del
ClinVar RefSeq Alternation Syntax
NM_001195799.2:c.2460_*4del
Clinical Significance Description
Uncertain significance
Clinical Significance Last Update
2022-12-10
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV003410581
ClinVar Disease
LDLR-related disorder
Drugs