Annotation Detail

Information
Associated Genes
TLR4
Associated Variants
ENSG00000285082 c.140+4595C>T, TLR4 p.Thr399Ile (p.T399I) ( ENST00000355622.8, ENST00000394487.5, ENST00000472304.2 )
ENSG00000285082 c.140+4595C>T, TLR4 p.Thr399Ile (p.T399I) ( ENST00000355622.8, ENST00000394487.5, ENST00000472304.2 )
Associated Disease
COPD, severe early onset
Source Database
ClinVar
Description
NM_138554.5(TLR4):c.1196C>T (p.Thr399Ile) AND COPD, severe early onset
ClinVar Allele ID
21700
ClinVar RefSeq Alternation Syntax
NM_138557.3:c.596C>T
ClinVar RefSeq Alternation Syntax
NM_138554.5:c.1196C>T
ClinVar RefSeq Alternation Syntax
NM_003266.4:c.1076C>T
Clinical Significance Description
Uncertain significance
Clinical Significance Last Update
2023-09-01
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV003390650
ClinVar Disease
COPD, severe early onset
Observed Origin Sample
germline
Drugs