Annotation Detail

Information
Associated Genes
HBB LOC107133510 LOC110006319
Associated Variants
HBB c.316-2A>G ( ENST00000335295.4, ENST00000647020.1 )
HBB c.316-2A>G ( ENST00000335295.4, ENST00000647020.1 )
Associated Disease
Dominant beta-thalassemia Erythrocytosis, familial, 6 Malaria, susceptibility to Beta-thalassemia HBB/LCRB Hereditary persistence of fetal hemoglobin Heinz body anemia Hb SS disease Methemoglobinemia, beta-globin type
Source Database
ClinVar
Description
NM_000518.5(HBB):c.316-2A>G AND multiple conditions
ClinVar Allele ID
34043
ClinVar RefSeq Alternation Syntax
NM_000518.5:c.316-2A>G
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2023-11-07
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV003389313
ClinVar Disease
Hereditary persistence of fetal hemoglobin
ClinVar Disease
Beta-thalassemia HBB/LCRB
ClinVar Disease
Hb SS disease
ClinVar Disease
Malaria, susceptibility to
ClinVar Disease
Erythrocytosis, familial, 6
ClinVar Disease
Dominant beta-thalassemia
ClinVar Disease
Heinz body anemia
ClinVar Disease
Methemoglobinemia, beta-globin type
Observed Origin Sample
germline
Drugs