Annotation Detail

Information
Associated Genes
RYR1 LOC126862902
Associated Variants
RYR1 p.Ile2781ArgfsTer49 (p.I2781Rfs*49) ( ENST00000355481.8, ENST00000359596.8, ENST00000689936.2, ENST00000713952.1, ENST00000713953.1 )
RYR1 p.Ile2781ArgfsTer49 (p.I2781Rfs*49) ( ENST00000355481.8, ENST00000359596.8, ENST00000689936.2, ENST00000713952.1, ENST00000713953.1 )
RYR1 p.His3981Tyr (p.H3981Y) ( ENST00000355481.8, ENST00000359596.8, ENST00000689936.2, ENST00000713952.1, ENST00000713953.1 )
RYR1 p.His3981Tyr (p.H3981Y) ( ENST00000355481.8, ENST00000359596.8, ENST00000689936.2, ENST00000713952.1, ENST00000713953.1 )
Associated Disease
Congenital multicore myopathy with external ophthalmoplegia
Source Database
ClinVar
Description
NM_000540.3(RYR1):c.[11941C>T;8342_8343del] AND Congenital multicore myopathy with external ophthalmoplegia
ClinVar Allele ID
581552
ClinVar Allele ID
38833
ClinVar RefSeq Alternation Syntax
NM_001042723.2:c.8342_8343del
ClinVar RefSeq Alternation Syntax
NM_000540.3:c.11941C>T
ClinVar RefSeq Alternation Syntax
NM_000540.3:c.8342_8343del
ClinVar RefSeq Alternation Syntax
NM_001042723.2:c.11926C>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2010-11-01
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV003388645
ClinVar Disease
Congenital multicore myopathy with external ophthalmoplegia
Observed Origin Sample
germline
Pubmed
20839240
Drugs