Annotation Detail

Information
Associated Genes
CHEK2
Associated Variants
CHEK2 p.Glu64Lys (p.E64K) ( ENST00000348295.7, ENST00000382580.6, ENST00000402731.6, ENST00000403642.5, ENST00000404276.6, ENST00000405598.5, ENST00000425190.7, ENST00000649563.1, ENST00000650281.1 )
CHEK2 p.Glu64Lys (p.E64K) ( ENST00000348295.7, ENST00000382580.6, ENST00000402731.6, ENST00000403642.5, ENST00000404276.6, ENST00000405598.5, ENST00000425190.7, ENST00000649563.1, ENST00000650281.1 )
Associated Disease
Predisposition to cancer
Source Database
ClinVar
Description
NM_007194.4(CHEK2):c.190G>A (p.Glu64Lys) AND Predisposition to cancer
ClinVar Allele ID
133525
ClinVar RefSeq Alternation Syntax
NM_007194.4:c.190G>A
ClinVar RefSeq Alternation Syntax
NM_001257387.2:c.-588G>A
ClinVar RefSeq Alternation Syntax
NM_001349956.2:c.190G>A
ClinVar RefSeq Alternation Syntax
NM_145862.2:c.190G>A
ClinVar RefSeq Alternation Syntax
NM_001005735.2:c.190G>A
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2022-01-03
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV003153376
ClinVar Disease
Predisposition to cancer
Observed Origin Sample
germline
Drugs