Annotation Detail

Information
Associated Genes
ARSA
Associated Variants
ARSA p.Leu430Pro (p.L430P) ( ENST00000216124.10, ENST00000356098.9, ENST00000395619.3, ENST00000395621.7, ENST00000453344.6 )
ARSA p.Leu430Pro (p.L430P) ( ENST00000216124.10, ENST00000356098.9, ENST00000395619.3, ENST00000395621.7, ENST00000453344.6 )
Associated Disease
metachromatic leukodystrophy
Source Database
ClinVar
Description
NM_000487.6(ARSA):c.1289T>C (p.Leu430Pro) AND Metachromatic leukodystrophy
ClinVar Allele ID
79010
ClinVar RefSeq Alternation Syntax
NM_001085426.3:c.1289T>C
ClinVar RefSeq Alternation Syntax
NM_001085425.3:c.1289T>C
ClinVar RefSeq Alternation Syntax
NM_001085427.3:c.1289T>C
ClinVar RefSeq Alternation Syntax
NM_000487.6:c.1289T>C
ClinVar RefSeq Alternation Syntax
NM_001085428.3:c.1031T>C
ClinVar RefSeq Alternation Syntax
NM_001362782.2:c.1031T>C
Clinical Significance Description
Conflicting interpretations of pathogenicity
Clinical Significance Last Update
2023-08-25
Clinical Significance Review Status
criteria provided, conflicting interpretations
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002514296
ClinVar Disease
Metachromatic leukodystrophy
Observed Origin Sample
germline
Observed Origin Sample
not applicable
Drugs