Annotation Detail

Information
Associated Genes
NF1
Associated Variants
NF1 p.Arg914Trp (p.R914W) ( ENST00000356175.7, ENST00000358273.9, ENST00000691014.1, ENST00000696138.1 )
NF1 p.Arg914Trp (p.R914W) ( ENST00000356175.7, ENST00000358273.9, ENST00000691014.1, ENST00000696138.1 )
Associated Disease
neurofibromatosis-Noonan syndrome Café-au-lait macules with pulmonary stenosis Neurofibromatosis, type 1 Neurofibromatosis, familial spinal juvenile myelomonocytic leukemia
Source Database
ClinVar
Description
NM_001042492.3(NF1):c.2740C>T (p.Arg914Trp) AND multiple conditions
ClinVar Allele ID
574395
ClinVar RefSeq Alternation Syntax
NM_000267.3:c.2740C>T
ClinVar RefSeq Alternation Syntax
NM_001042492.3:c.2740C>T
Clinical Significance Description
Uncertain significance
Clinical Significance Last Update
2022-03-14
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002507190
ClinVar Disease
Neurofibromatosis-Noonan syndrome
ClinVar Disease
Neurofibromatosis, type 1
ClinVar Disease
Café-au-lait macules with pulmonary stenosis
ClinVar Disease
Juvenile myelomonocytic leukemia
ClinVar Disease
Neurofibromatosis, familial spinal
Observed Origin Sample
unknown
Drugs