Annotation Detail

Information
Associated Genes
SCN5A LOC110121269
Associated Variants
SCN5A p.Ala997Ser (p.A997S) ( ENST00000333535.9, ENST00000413689.6, ENST00000414099.6, ENST00000423572.7, ENST00000449557.6, ENST00000450102.6, ENST00000455624.6 )
SCN5A p.Ala997Ser (p.A997S) ( ENST00000333535.9, ENST00000413689.6, ENST00000414099.6, ENST00000423572.7, ENST00000449557.6, ENST00000450102.6, ENST00000455624.6 )
Associated Disease
Sick sinus syndrome 1 Atrial fibrillation, familial, 10 Brugada syndrome 1 dilated cardiomyopathy 1E sudden infant death syndrome long QT syndrome 3 Ventricular fibrillation, paroxysmal familial, type 1 Progressive familial heart block, type 1A
Source Database
ClinVar
Description
NM_000335.5(SCN5A):c.2989G>T (p.Ala997Ser) AND multiple conditions
ClinVar Allele ID
24427
ClinVar RefSeq Alternation Syntax
NM_198056.3:c.2989G>T
ClinVar RefSeq Alternation Syntax
NM_001099405.2:c.2989G>T
ClinVar RefSeq Alternation Syntax
NM_001160161.2:c.2989G>T
ClinVar RefSeq Alternation Syntax
NM_000335.5:c.2989G>T
ClinVar RefSeq Alternation Syntax
NM_001099404.2:c.2989G>T
ClinVar RefSeq Alternation Syntax
NM_001160160.2:c.2989G>T
ClinVar RefSeq Alternation Syntax
NM_001354701.2:c.2989G>T
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2022-02-15
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002504775
ClinVar Disease
Progressive familial heart block, type 1A
ClinVar Disease
Long QT syndrome 3
ClinVar Disease
Ventricular fibrillation, paroxysmal familial, type 1
ClinVar Disease
Brugada syndrome 1
ClinVar Disease
Sick sinus syndrome 1
ClinVar Disease
Dilated cardiomyopathy 1E
ClinVar Disease
SUDDEN INFANT DEATH SYNDROME
ClinVar Disease
Atrial fibrillation, familial, 10
Observed Origin Sample
unknown
Drugs