Annotation Detail

Information
Associated Genes
FGFR2
Associated Variants
FGFR2 p.Pro263Leu (p.P263L) ( ENST00000369060.8, ENST00000369061.8, ENST00000369056.5, ENST00000360144.7, ENST00000369059.5, ENST00000346997.6, ENST00000351936.11, ENST00000457416.7, ENST00000478859.5, ENST00000358487.10, ENST00000357555.9, ENST00000356226.8, ENST00000613048.4, ENST00000638709.2, ENST00000682550.1, ENST00000682772.1, ENST00000683211.1, ENST00000684153.1 )
FGFR2 p.Pro263Leu (p.P263L) ( ENST00000346997.6, ENST00000351936.11, ENST00000356226.8, ENST00000357555.9, ENST00000358487.10, ENST00000360144.7, ENST00000369056.5, ENST00000369059.5, ENST00000369060.8, ENST00000369061.8, ENST00000457416.7, ENST00000478859.5, ENST00000613048.4, ENST00000638709.2, ENST00000682550.1, ENST00000682772.1, ENST00000683211.1, ENST00000684153.1 )
Associated Disease
Familial scaphocephaly syndrome, McGillivray type Saethre-Chotzen syndrome Gastric cancer Levy-Hollister syndrome Crouzon syndrome Acrocephalosyndactyly type I Jackson-Weiss syndrome Bent bone dysplasia syndrome 1 Pfeiffer syndrome Beare-Stevenson cutis gyrata syndrome Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis
Source Database
ClinVar
Description
NM_000141.5(FGFR2):c.788C>T (p.Pro263Leu) AND multiple conditions
ClinVar Allele ID
993743
ClinVar RefSeq Alternation Syntax
NM_001144914.1:c.749-4811C>T
ClinVar RefSeq Alternation Syntax
NR_073009.2:n.1076C>T
ClinVar RefSeq Alternation Syntax
NM_001144916.2:c.443C>T
ClinVar RefSeq Alternation Syntax
NM_022969.1:c.788C>T
ClinVar RefSeq Alternation Syntax
NM_022970.4:c.788C>T
ClinVar RefSeq Alternation Syntax
NM_023029.2:c.521C>T
ClinVar RefSeq Alternation Syntax
NM_000141.5:c.788C>T
ClinVar RefSeq Alternation Syntax
NM_001144918.2:c.443C>T
ClinVar RefSeq Alternation Syntax
NM_001144913.1:c.788C>T
ClinVar RefSeq Alternation Syntax
NM_001144917.2:c.788C>T
ClinVar RefSeq Alternation Syntax
NM_001320658.2:c.788C>T
ClinVar RefSeq Alternation Syntax
NM_001144919.2:c.521C>T
ClinVar RefSeq Alternation Syntax
NM_001320654.2:c.104C>T
ClinVar RefSeq Alternation Syntax
NM_001144915.2:c.521C>T
Clinical Significance Description
Uncertain significance
Clinical Significance Last Update
2022-03-24
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002499544
ClinVar Disease
Pfeiffer syndrome
ClinVar Disease
Acrocephalosyndactyly type I
ClinVar Disease
Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis
ClinVar Disease
Saethre-Chotzen syndrome
ClinVar Disease
Jackson-Weiss syndrome
ClinVar Disease
Bent bone dysplasia syndrome 1
ClinVar Disease
Beare-Stevenson cutis gyrata syndrome
ClinVar Disease
Familial scaphocephaly syndrome, McGillivray type
ClinVar Disease
Gastric cancer
ClinVar Disease
Levy-Hollister syndrome
ClinVar Disease
Crouzon syndrome
Observed Origin Sample
unknown
Drugs