Annotation Detail

Information
Associated Genes
MECP2
Associated Variants
MECP2 p.Pro399Leu (p.P399L) ( ENST00000303391.11, ENST00000407218.5, ENST00000415944.4, ENST00000453960.7, ENST00000628176.2 )
MECP2 p.Pro399Leu (p.P399L) ( ENST00000303391.11, ENST00000407218.5, ENST00000415944.4, ENST00000453960.7, ENST00000628176.2 )
Associated Disease
Rett syndrome Autism, susceptibility to, X-linked 3 syndromic X-linked intellectual disability Lubs type Severe neonatal-onset encephalopathy with microcephaly X-linked intellectual disability-psychosis-macroorchidism syndrome
Source Database
ClinVar
Description
NM_001110792.2(MECP2):c.1196C>T (p.Pro399Leu) AND multiple conditions
ClinVar Allele ID
153115
ClinVar RefSeq Alternation Syntax
NM_001369391.2:c.881C>T
ClinVar RefSeq Alternation Syntax
NM_004992.4:c.1160C>T
ClinVar RefSeq Alternation Syntax
NM_001316337.2:c.881C>T
ClinVar RefSeq Alternation Syntax
NM_001369392.2:c.881C>T
ClinVar RefSeq Alternation Syntax
NM_001369393.2:c.881C>T
ClinVar RefSeq Alternation Syntax
NM_001369394.2:c.881C>T
ClinVar RefSeq Alternation Syntax
NM_001386138.1:c.491C>T
ClinVar RefSeq Alternation Syntax
NM_001386137.1:c.491C>T
ClinVar RefSeq Alternation Syntax
NM_001110792.2:c.1196C>T
ClinVar RefSeq Alternation Syntax
NM_001386139.1:c.491C>T
Clinical Significance Description
Likely benign
Clinical Significance Last Update
2022-01-03
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002498651
ClinVar Disease
Severe neonatal-onset encephalopathy with microcephaly
ClinVar Disease
Syndromic X-linked intellectual disability Lubs type
ClinVar Disease
Rett syndrome
ClinVar Disease
Autism, susceptibility to, X-linked 3
ClinVar Disease
X-linked intellectual disability-psychosis-macroorchidism syndrome
Observed Origin Sample
unknown
Drugs