Annotation Detail

Information
Associated Genes
HBB LOC106099062 LOC107133510
Associated Variants
HBB c.92+2T>C ( ENST00000485743.1, ENST00000335295.4, ENST00000647020.1 )
HBB c.92+2T>C ( ENST00000335295.4, ENST00000485743.1, ENST00000647020.1 )
Associated Disease
Heinz body anemia Methemoglobinemia, beta-globin type Hereditary persistence of fetal hemoglobin alpha thalassemia Dominant beta-thalassemia Malaria, susceptibility to Erythrocytosis, familial, 6 Hb SS disease Beta-thalassemia HBB/LCRB
Source Database
ClinVar
Description
NM_000518.5(HBB):c.92+2T>C AND multiple conditions
ClinVar Allele ID
44998
ClinVar RefSeq Alternation Syntax
NM_000518.5:c.92+2T>C
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2021-09-10
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002496456
ClinVar Disease
Hereditary persistence of fetal hemoglobin
ClinVar Disease
Beta-thalassemia HBB/LCRB
ClinVar Disease
Hb SS disease
ClinVar Disease
alpha Thalassemia
ClinVar Disease
Malaria, susceptibility to
ClinVar Disease
Erythrocytosis, familial, 6
ClinVar Disease
Dominant beta-thalassemia
ClinVar Disease
Heinz body anemia
ClinVar Disease
Methemoglobinemia, beta-globin type
Observed Origin Sample
unknown
Drugs