Annotation Detail

Information
Associated Genes
HBB LOC106099062 LOC107133510
Associated Variants
HBB p.Val68AlafsTer5 (p.V68Afs*5) ( ENST00000485743.1, ENST00000335295.4, ENST00000647020.1 )
HBB p.Val68AlafsTer5 (p.V68Afs*5) ( ENST00000335295.4, ENST00000485743.1, ENST00000647020.1 )
Associated Disease
Hereditary persistence of fetal hemoglobin Dominant beta-thalassemia Malaria, susceptibility to Methemoglobinemia, beta-globin type Erythrocytosis, familial, 6 alpha thalassemia Hb SS disease Heinz body anemia Beta-thalassemia HBB/LCRB
Source Database
ClinVar
Description
NM_000518.5(HBB):c.203_204del (p.Val68fs) AND multiple conditions
ClinVar Allele ID
44967
ClinVar RefSeq Alternation Syntax
NM_000518.5:c.203_204del
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2021-11-24
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002496454
ClinVar Disease
Hereditary persistence of fetal hemoglobin
ClinVar Disease
Beta-thalassemia HBB/LCRB
ClinVar Disease
Hb SS disease
ClinVar Disease
alpha Thalassemia
ClinVar Disease
Malaria, susceptibility to
ClinVar Disease
Erythrocytosis, familial, 6
ClinVar Disease
Dominant beta-thalassemia
ClinVar Disease
Heinz body anemia
ClinVar Disease
Methemoglobinemia, beta-globin type
Observed Origin Sample
unknown
Drugs